Ongoing Research References
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MPIGH (EMP) Trials: A series of trials (e.g., Early Malnutrition Prevention trials) aimed at improving childhood malnutrition outcomes, with research outputs expected by 2030 as part of TROPGAN’s strategic plan.
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GItools Study: Ongoing research utilizing GItools to measure intestinal barrier failure, absorption, immunology, or the microbiome, with grant applications in progress to expand this work.
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Co-SAM Trial: A phase III multi-arm randomized controlled trial for severe acute malnutrition across Zambia, Zimbabwe, and Kenya, currently ongoing with anticipated publications forthcoming.
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GIprevalence Study: An ongoing study investigating the prevalence of gastrointestinal disorders, with data collection and analysis still in progress.
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Other Ongoing Studies: Includes the TAME interventions, HOPE-SAM trial, and additional collaborative projects with partners like Zvitambo and Queen Mary University of London, with results pending publication.
Original peer-reviewed research articles
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2025
Full Articles
Links to the complete list of articles for each researcher are provided below:
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Prof. Paul Kelly – Google Scholar, PubMed, ORCID, Scopus
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Prof. Violet Kayamba – Google Scholar, PubMed, ORCID, Scopus
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Prof. Edford Sinkala – Google Scholar, PubMed, ORCID, Scopus
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Dr. Beatrice C. Amadi - Google Scholar, PubMed, ORCID, Scopus
Excerpt of Peer-Reviewed Research articles
2025
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Hracs L, Windsor JW, Gorospe J, Cummings M, Coward S, Buie MJ, Quan J, Goddard Q, Caplan L, Markovinović A, Williamson T, Abbey Y, Abreu MT, Ali RAR, Abdullah M, Altuwaijri M, Ahuja V, Balderramo D, Banerjee R, Benchimol EI, Bernstein CN, Brunet‑Mas E, Burisch J, Chong VH, Dotan I, Dutta U, El Ouali S, Forbes A, Forss A, Gearry R, Dao VH, Hartono JL, Hilmi I, Hodges P, Jones G‑R, Juliao‑Baños F, Kaibullayeva J, Kelly P, Kobayashi T, Kotze PG, Lakatos PL, Lees C, Limsrivilai J, Lo B, Loftus EV, Ludvigsson JF, Mak JWY, Ng KK, Okabayashi S, Olén O, Panaccione R, Paudel MS, Quaresma AB, Rubin DT, Simadibrata M, Sun Y, Suzuki H, Toro M, Turner D, Vergara BI, Wei SC, Yamamoto‑Furusho JK, Yang S‑K, Ng SC, Kaplan GG; GIVES‑21 Research Group. The Global Evolution of Inflammatory Bowel Disease across Four Epidemiologic Stages. Nature. 2025;642:458–466.
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Mweetwa MN, Ahsan K, McNulty NP, Besa E, Barratt MJ, Posma JM, Amadi B, Gordon JI, Kelly P. Small intestinal microbiota in Zambian children with stunting and severe acute malnutrition. Philosophical Transactions of the Royal Society B; in press (2025).
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Mweetwa MN, Ahsan K, Louis‑Auguste J, Besa E, Posma JM, McNulty N, Barrat MJ, Gordon J, Kelly P. Intestinal microbiome changes in response to amino acid and micronutrient supplementation: secondary analysis of the AMAZE trial. Gut Microbiome. 2025;6:e16(1–16). doi:10.1017/gmb.2025.10011.
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Vinikoor MJ, Walker A, Nsokolo B, Musonda T, Muula G, Michailidis E, Wandeler G, Alatrakchi N, Kelly P, Le DB, Voges A, Lübke N, Kanunga A, Bosomprah S, Bhattacharya D, Chibundi C, Bwalya G, Musukuma‑Chifulo K, Suslov A, Feuerherd M, Heim MH, Schwartz RE, Chung RT, Lauer G, Sinkala E, Timm J. Whole genome sequencing of hepatitis B virus genotypes E and A in Zambia reveals limited viral diversity in HIV coinfection-Open Forum Infectious Diseases; in press (2025).
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Modoc DP, Ahmed S, Chisenga M, Cox SE, Dasgupta R, Duazo P, Faurholt‑Jepsen D, Kasonka L, Kelly P, Keogh R, Kweka B, Krogh‑Madsen R, Lee N, Malindisa E, Nitsch D, Ngoya P, PrayGod G, Shaw JA, Solon JA, Tembo MJ, Trilok‑Kumar G, Filteau S. Associations of prior wasting malnutrition with later indicators of glucose tolerance across four countries in Africa and Asia: the SAMPA cohort study. American Journal of Clinical Nutrition. 2025. doi:10.1016/j.ajcnut.2025.07.032.
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Mweetwa M, Kelly P, Posma J. A meta‑analysis of gut microbiome research in malnourished African populations: a natural language processing approach. Philosophical Transactions of the Royal Society B; in press (2025).
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Sibande J, Hankolwe MN, Kelly P, Kayamba V. Fasting gastric juice melatonin levels in relation to gastroduodenal pathologies among Zambian patients: A cross‑sectional study. Health Science Reports. 2025;8:e71053. doi:10.1002/hsr2.71053.
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PrayGod G, Kweka B, Malindisa E, Rehman AM, Frikke‑Schmidt R, Christoffersen C, Krogh‑Madsen R, Friis H, Kelly P, Filteau S. Association of environmental enteropathy with prediabetes and diabetes: a cross‑sectional study among Tanzanian adults. PLOS ONE. 2025;20:e0327166. doi:10.1371/journal.pone.0327166.
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Shivakumar N, Kashyap S, Morrison DJ, Devi S, Mweetwa MN, Hodges P, Kurpad AV, Kelly P. Association of intestinal amino acid absorption with uptake of lactulose and rhamnose in adults with environmental enteropathy. American Journal of Tropical Medicine and Hygiene; in press (2025).
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Hodges P, Malambo M, Kawana W, Besa E, Mweetwa M, Kayamba V, Mudenda V, Croft NM, Kelly P. Environmental enteropathy and inflammatory bowel disease are not mutually exclusive. Digestive and Liver Disease. 2025;57:1622–1629. doi:10.1016/j.dld.2025.05.001.
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Bwakura‑Dangarembizi M, Amadi B, Singa BO, Muyemayema S, Ngosa D, Mwalekwa L, Ngao N, Kazhila L, Mutasa B, Mpofu E, Mudawarima L, Gonzales GB, Mudzingwa S, Mutenda M, Keter LK, Mutasa K, Njunge JM, Jones H, Phiri TN, Mudibo E, Chulu N, Majo FD, Chasekwa B, Tembo A, Nyabinda C, Oduol C, Sauramba V, Tavengwa NV, Langhaug L, Cordani I, Smuk M, Jaki T, Ntozini R, Walson J, Tickell KD, Berkley J, Kelly P, Prendergast AJ; Co‑SAM Trial Team. An adaptive multiarm randomised trial of biomedical and psychosocial interventions to improve convalescence following severe acute malnutrition in sub‑Saharan Africa: Co‑SAM trial protocol. BMJ Open. 2025;15:e093758. doi:10.1136/bmjopen-2024-093758.
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Phiri TN, Weatherill JW, Monford‑Sanchez E, Serrano‑Contreras JI, Melvin C, Kunaka M, Chisenga I, Ngalande P, Mweetwa MN, Besa E, Haider T, Mandal N, Thompson AJ, Edwards CA, Bourke CD, Robertson RC, Posma JM, Banda R, Mwiinga M, Kazhila L, Katsidzira L, Bwakura‑Dangarembizi M, Amadi B, Garcia‑Perez I, Maitland K, Marchesi JR, Morrison DJ, Frost G, Kelly P. Novel gastrointestinal tools (GI Tools) for evaluating gut functional capacity in adults with environmental enteropathy in Zambia and Zimbabwe: A cross‑sectional study protocol. F1000Research. 2025;13:956. doi:10.12688/f1000research.154471.2.
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Thompson A, Hughes M, Anastasova S, Conklin L, Thomas T, Leggett C, Faubion W, Miller T, Delaney P, Lacombe L, Loiseau S, Meining A, Richards‑Kortum R, Tearney G, Kelly P, Yang G‑Z. The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction. Nature Reviews Gastroenterology & Hepatology; in press (2025).
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2024
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Mudibo E, Bogaert J, Tigoi C, Ngari M, Singa B, Lancioni C, Diallo A, Mbale E, Mupere E, Mukisa J, Thitiri J, Timbwa M, Omer E, Ngao N, Musyimi R, Kahindi E, Bamouni R, Bandsma R, Kelly P, Prendergast A, McGrath C, Tickell K, Walson J, Berkley J, Njunge J, Gonzales G.Systemic biological mechanisms underpin poor post‑discharge growth among severely wasted children with HIV.Nature Communications. 2024;15:10299.
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Shivakumar N, Huq S, Paredes‑Olortegui M, Konyole SO, Devi S, Yazbeck R, Owino VO, Brouwer AF, Kosek MN, Kelly P, Morrison DJ, Lee GO. A cross‑sectional study of associations between the 13C‑sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy. Am J Clin Nutr. 2024. doi:10.1016/j.ajcnut.2024.10.001.
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Kayamba V, Munshi H, Hankolwe MN, Kavimba CK, Zyambo K, Chongwe G, Knaze, Park JY, Kelly P. Nationwide survey of Helicobacter pylori seropositivity and gastric atrophy in Zambia. Helicobacter. 2024;29:e13096. doi:10.1111/hel. 13096.
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Malindisa EK, Dika H, Rehman AM, Kweka B, Todd J, Olsen MF, Krogh‑Madsen R, Frikke‑Schmidt R, Friis H, Faurholt‑Jepsen D, Kelly P, Filteau S, PrayGod G. Associations between dietary patterns and intestinal inflammation among HIV‑infected and uninfected adults: A cross‑sectional study in Tanzania. PLOS ONE. 2024;19:e0311693. doi:10.1371/journal.pone.0311693.
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Zulqarnain F, Zhao X, Setchell KDR, Sharma Y, Fernandes P, Srivastava A, Ehsan L, Jain V, Raghavan S, Moskaluk C, Haberman Y, Denson LA, Mehta K, Iqbal NT, Rahman N, Sadiq K, Ahmad Z, Idress R, Iqbal J, Ahmed S, Hotwani A, Umrani F, Kelly P, Amadi B, Moore SR, Brown DE, Ali SA, Syed S. Integrative ‘omics and machine‑learning‑based image analyses of environmental enteric dysfunction reveal an immunologic and metabolic pathogenesis of intestinal failure.iScience. 2024;27:110013. doi:10.1016/j.isci.2024.110013.
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Kayamba V, Mubbunu M, Kelly P. Endoscopic diagnosis of gastric and oesophageal cancer in Lusaka, Zambia: a retrospective analysis. BMC Gastroenterology. 2024;24:122. doi:10.1186/s12876-024-03187-x.
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Monfort Sanchez E, Avery J, Gan J, Qian J, Mandal N, Agarwal A, Mwiinga M, Banda R, Darzi A, Kelly P, Thompson AJ.Transcutaneous fluorescence spectroscopy: development and characterisation of a compact, portable, and fiber‑optic sensor.J Biomed Opt. 2024;29:027003. doi:10.1117/1.JBO.29.2.027003.
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Kelly P, VanBuskirk K, Coomes D, Mouksassi S, Smith G, Jamil Z, Hossain MS, Syed S, Marie C, Tarr PI, Sullivan PB, Petri WA, Denno DM, Ahmed T, Mahfuz M, Ali SA, Moore SR, Ndao IM, Tearney GJ, Yilmaz OH, Raghavan SS, Moskaluk CA, Liu T‑C.Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with US children. Am J Clin Nutr. 2024;120:S15–30.
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Iqbal NT, Lawrence S, Ahmed T, Chandwe K, Fahim SM, Houpt ER, Kabir F, Kelly P, Liu J, Mahfuz M, Mweetwa M, VanBuskirk K, Tarr PI, Denno DM.Enteric pathogens' relationship with small bowel histological features of environmental enteric dysfunction in a multi‑country cohort study.Am J Clin Nutr. 2024;120:S84–93.
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VanBuskirk K, Mweetwa M, Kolterman T, Raghavan S, Ahmed T, Ali SA, Khodeza SM, Begum N, Besa E, Denno DM, Jamil Z, Kelly P, Mahfuz M, Moore SR, Mouksassi S, Petri WA, Tarr PI, Sullivan PB, Moskaluk C. Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction. Am J Clin Nutr. 2024;120:S31–40. Read the full article on Google Scholar
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Musonda T, Wallace MS, Patel H, Martin OP, Oetheimer C, Mwakamui S, Sinkala E, Nsokolo B, Kanunga A, Lauer G, Chung RT, Wandeler G, Bhattacharya D, Kelly P, Alatrakchi N, Vinikoor MJ. New window into hepatitis B in Africa: Liver sampling combined with single-cell omics enables deep and longitudinal assessment of intrahepatic immunity in Zambia. J Infect Dis. 2024;230:e1171–1175. doi:10.1093/infdis/jiae054.
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Malique A, Sun S, Chandwe K, Amadi B, Haritunians T, Jain U, Muegge BD, Frein J, Sasaki Y, Foster A, Storer CE, Mengesha E, Kern J, McGovern DPB, Head RD, Kelly P, Liu TC. NAD+ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction. Sci Transl Med. 2024;16(728):eabq4145. doi:10.1126/scitranslmed.abq4145. Scholar:
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Sturgeon JP, Tome J, Dumbura C, Majo FD, Ngosa D, Mutasa K, Zyambo K, Besa E, Chandwe K, Kapoma C, Mwapenya B, Nathoo KJ, Bourke CD, Ntozini R, Chasekwa B, Smuk M, Bwakura‑Dangarembizi M, Amadi B, Kelly P, Prendergast AJ. Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in children with severe malnutrition.Sci Transl Med. 2024;16(736):eadh0673. doi:10.1126/scitranslmed.adh0673.
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Chandwe K, Bwakura‑Dangarembizi M, Amadi B, Tawodzera G, Ngosa D, Dzikiti A, Chulu N, Makuyana R, Zyambo K, Mutasa K, Mulenga C, Besa E, Sturgeon JP, Mudzingwa S, Simunyola B, Kazhila L, Zyambo M, Sonkwe H, Mutasa B, Chipunza M, Sauramba V, Langhaug L, Mudenda V, Murch SH, Hill S, Playford RJ, VanBuskirk K, Prendergast AJ, Kelly P.Novel therapies for malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: a multi‑arm phase II trial. Nature Communications. 2024;15:2910. doi:10.1038/s41467-024-45528-0.
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Evans C, Mutasa K, Rukobo S, Govha M, Mushayanembwa P, Chasekwa B, Majo FD, Tavengwa NV, Broad J, Noble C, Gough EK, Kelly P, Bourke CD, Humphrey JH, Ntozini R, Prendergast AJ.Inflammation and CMV viremia during pregnancy drive mortality and shape immune development in HIV‑exposed infants.Nature Communications. 2024;15:2909. doi:10.1038/s41467-023-44166-2.
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Kebotsamang T, Munkombwe D, Bwalya L, Kelly P, Kayamba V. Prevalence of clarithromycin‑resistant Helicobacter pylori strains in Zambia: A sub‑Saharan African country. Digestive Diseases. 2024. doi:10.1159/000535454.
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2023
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Phiri TN, Mutasa K, Rukobo S, Govha M, Mushayanembwa P, Mwakamui S, Haider T, Zyambo K, Dumbura C, Tome J, Runodamoto T, Chidamba L, Majo FD, Ngosa D, Chandwe K, Kapoma C, Mwapenya B, Mufukari W, Sturgeon JP, Robertson RC, Smuk M, Ntozini R, Nathoo K, Amadi B, Kelly P, Bwakura‑Dangarembizi M, Prendergast AJ, Bourke CD.Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells.Science Advances. 2023;9:eadh2284. doi:10.1126/sciadv.adh2284.
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Mweetwa M, Haritunians T, Dube S, Chandwe K, Amadi B, Zyambo K, Liu T‑C, McGovern D, Kelly P.Genetic variation in Environmental Enteropathy and stunting in Zambian children: A pilot genome-wide association study using the H3Africa chip.PLOS ONE. 2023;18(9):e0291311. doi:10.1371/journal.pone.0291311.
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Sturgeon JP, Mufukari W, Tome J, Dumbura C, Majo FD, Ngosa D, Chandwe K, Kapoma C, Mutasa K, Nathoo KJ, Bourke CD, Ntozini R, Bwakura‑Dangarembizi M, Amadi B, Kelly P, Prendergast AJ; HOPE‑SAM study team. Risk factors for inpatient mortality among children with severe acute malnutrition in Zimbabwe and Zambia.European Journal of Clinical Nutrition. 2023;77:895–904. doi:10.1038/s41430-023-01320-9.
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Mak JWY, Sun Y, Limsrivilai J, Abdullah M, Kaibullayeva J, Balderramo D, Vergara BI, Paudel MS, Banerjee R, Hilmi I, Ali RAR, Wei SC, Ng KK, Altuwaijri M, Kelly P, Yamamoto‑Furusho JK, Kotze PG, Ahuja V, Chong VH, Dao HV, Abbey Y, Ching JYL, Ho A, Chan AKW, Bernstein CN, Gearry RB, Abreu M, Rubin DT, Dotan I, Hracs L, Kaplan GG, Ng SC; GIVES‑21 Consortium.Development of the global inflammatory bowel disease visualisation of epidemiology studies in the 21st century (GIVES‑21).BMC Medical Research Methodology. 2023;23:129. doi:10.1186/s12874-023-01944-2.
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Besa EC, Tembo MJ, Mulenga C, Mweetwa M, Choudhry N, Chandwe K, Storer C, Head R, Haritunians T, McGovern D, Amadi B, Kwenda G, Peiris M, Kelly P. Potential determinants of low circulating GLP‑2 concentrations in Zambian children with non‑responsive stunting. Experimental Physiology. 2023;108:568–580. doi:10.1113/EP090492.
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2022
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Bwakura‑Dangarembizi M, Dumbura C, Amadi B, Singa BO, Ngosa D, Majo FD, Piper JD, Sturgeon JP, Nathoo KJ, Norris S, Chasekwa B, Ntozini R, Wells JC, Kelly P, Prendergast AJ; HOPE‑SAM study team. Fat and lean mass predict time to hospital readmission or mortality in children treated for complicated severe acute malnutrition in Zimbabwe and Zambia. British Journal of Nutrition. 2022:1–25. doi:10.1017/S0007114522004056.
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Ahmed S, PrayGod G, R. Lee N, et al.Long‑term health after Severe Acute Malnutrition in children and adults – the role of the Pancreas (SAMPA): Protocol. F1000Research. 2022;11:777. doi:10.12688/f1000research.123389.2.
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Kayamba V, Mulenga C, Mubbunu M, Kazhila L, Hodges P, Kelly P.Association between oesophageal cancer and biomass smoke exposure: a case‑control study.eCancer Medical Science. 2022;16:1422. doi:10.3332/ecancer 2022.1422.
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Kayamba V, Butt J, Varga M, Shibemba A, Piazuelo M, Wilson K, Zyambo K, Mwakamui S, Mulenga Chola, Waterboer T, Epplein M, Heimburger DC, Atadzhanov M, Kelly P. Serum antibodies to selected Helicobacter pylori antigens are associated with active gastritis in patients seen at the University Teaching Hospital in Lusaka, Zambia. Malawi Medical Journal. 2022;34:17–24.
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Zyambo K, Kelly P, Kayamba V. Evaluation of an association between gastric cancer and plasma selenium in Zambian adults: a case‑control study. eCancer Medical Science. 2022;16:1351. doi:10.3332/ecancer.. 2022.1351.
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Chandwe K, Zyambo K, Mulenga C, Haritunians T, Francois R, Amadi B, Kosek M, Heimburger D, McGovern D, Kelly P. Histo‑blood group antigens, enteropathogen carriage and environmental enteropathy in stunted Zambian children.Journal of Pediatric Gastroenterology and Nutrition. 2022;74:529–534. doi:10.1097/MPG.0000000000003343.
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Schillinger RJ, Mwakamui S, Mulenga C, Tembo M, Hodges P, Besa E, Chandwe K, Owino VO, Edwards CA, Kelly P, Morrison DJ.13C‑sucrose breath test for the non‑invasive assessment of environmental enteropathy in Zambian adults.Frontiers in Medicine. 2022;9:904339. doi:10.3389/fmed 2022.904339.
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Kummerlowe C, Mwakamui S, Hughes TK, Mulugeta N, Mudenda V, Besa E, Zyambo K, Shay JES, Fleming I, Vukovic M, Doran BA, Aicher TP, Wadsworth MH 2nd, Bramante JT, Uchida AM, Fardoos R, Asowata OE, Herbert N, Yilmaz ÖH, Kløverpris HN, Garber JJ, Ordovas‑Montañes J, Gartner ZJ, Wallach T, Shalek AK, Kelly P.Single‑cell profiling of environmental enteropathy reveals signatures of epithelial remodelling and immune activation. Science Translational Medicine. 2022;14:eabi8633. doi:10.1126/scitranslmed.abi8633.
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Mulenga C, Sviben S, Chandwe K, Amadi B, Kayamba V, Fitzpatrick JAJ, Mudenda V, Kelly P.Epithelial abnormalities in the small intestine of Zambian children with stunting.Frontiers in Medicine (Gastroenterology). 2022;9:849677. doi:10.3389/fmed. 2022.849677.
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Zyambo K, Hodges P, Chandwe K, Chisenga C, Mayimbo S, Amadi B, Kelly P, Kayamba V.Selenium status in adults and children in Lusaka, Zambia.Heliyon. 2022:e09782. doi:10.1016/j.heliyon.2022.e09782.
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Bwakura‑Dangarembizi M, Dumbura C, Amadi B, Chasekwa B, Ngosa D, Majo FD, Sturgeon JP, Chandwe K, Kapoma C, Bourke CD, Robertson RC, Nathoo KJ, Ntozini R, Norris SA, Kelly P, Prendergast AJ.Recovery of children following hospitalisation for complicated severe acute malnutrition in Zimbabwe and Zambia.Maternal & Child Nutrition. 2022;18:e13302. doi:10.1111/mcn. 13302.
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Zyambo K, Hodges P, Chandwe K, Mweetwa M, Westcott J, Krebs N, Amadi B, Kelly P.Reduced fractional absorption of zinc in children with environmental enteropathy in Zambia.Journal of Pediatric Gastroenterology and Nutrition. 2022;74:277–283. doi:10.1097/MPG.0000000000003292.
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Banda B, Siwila J, Mukubesa AN, Chitanga S, Kaonga P, Changula K, Simulundu E, Saasa N, Kelly P.Cryptosporidiosis is predominantly an urban, anthroponotic infectious disease among Zambian children. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2022;116:270–277. doi:10.1093/trstmh/trab121.
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Mwachiro M, Topazian HM, Kayamba V, Mulima G, Ogutu E, Erke M, Lenga G, Mutie T, Mukhwana E, Desalegn H, Berhe R, Meshesha BR, Kaimila B, Kelly P, Fleischer D, Dawsey SM, Topazian MD.Gastrointestinal endoscopy capacity in eastern Africa. Endoscopy International Open. 2022;9:E1827–E1836. doi:10.1055/a-1551-3343.
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Furch B, Mwakamui S, Sianongo S, Zyambo K, Heimburger D, Koethe JR, Kelly P. Contribution of Schistosoma mansoni to systemic inflammation and microbial translocation among persons with HIV in Zambia.Transactions of the Royal Society of Tropical Medicine and Hygiene. 2022;116:179–186. doi:10.1093/trstmh/trab103.
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Mbuki R, Chileya S, Thompson AJ, Kelly P, Kayamba V.Rapid testing of gut permeability using oral fluorescein and confocal laser endomicroscopy in Zambian adults.Transactions of the Royal Society of Tropical Medicine and Hygiene. 2022;115:1226–1228. doi:10.1093/trstmh/trab083.
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2021
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​Hodges P, Kelly P, Kayamba V.Helicobacter pylori infection and hypochlorhydria in Zambian adults and children: a secondary analysis.PLOS ONE. 2021;16:e0256487. doi:10.1371/journal.pone.0256487.
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Kelly P, Amadi B, Chandwe K, Besa E, Zyambo K, Chama M, Tarr PI, Shaikh N, Ndao IM, Storer C, Head R.Gene expression profiles compared in environmental and malnutrition enteropathy in Zambian children and adults.EBioMedicine. 2021;70:103509. doi:10.1016/j.ebiom.2021.103509.
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Amadi B, Zyambo K, Chandwe K, Besa E, Mulenga C, Mwakamui S, Siyumbwa S, Croft S, Banda R, Chipunza M, Chifunda K, Kazhila L, VanBuskirk K, Kelly P.Adaptation of the small intestine to microbial enteropathogens in Zambian children with stunting.Nature Microbiology. 2021;6:445–454. doi:10.1038/s41564-020-00849-w.
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Playford RJ, Choudhry N, Kelly P, Marchbank T. Effect of bovine colostrum with or without egg on in vitro bacterial‑induced intestinal damage with relevance for SIBO and infectious diarrhoea. Nutrients. 2021;13:1024. doi:10.3390/nu13031024.
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Syed S, Ehsan L, Shrivastava A, Sengupta S, Khan M, Kowsari K, Guleria S, Sali R, Kant K, Kang SJ, Sadiq K, Iqbal NT, Cheng L, Moskaluk CA, Kelly P, Amadi BC, Ali SA, Moore SR, Brown DE.Artificial Intelligence‑based analytics for diagnosis of small bowel enteropathies and black box feature detection.Journal of Pediatric Gastroenterology and Nutrition. 2021;72:833–841. doi:10.1097/MPG.0000000000003057.
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Bwakura‑Dangarembizi M, Dumbura C, Amadi B, Ngosa D, Majo FD, Nathoo KJ, Mwakamui S, Mutasa K, Chasekwa B, Norris SA, Ntozini R, Walker AS, Kelly P, Prendergast AJ. Risk factors for post‑discharge mortality following hospitalisation for severe acute malnutrition in Zimbabwe and Zambia. American Journal of Clinical Nutrition. 2021;113:665–674. doi:10.1093/ajcn/nqaa346.
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Chandwe K, Amadi B, Chipunza M, Zyambo M, Kelly P.Safety and ethics in endoscopic studies in children: evidence from the BEECH study in Zambia.Journal of Tropical Paediatrics. 2021;67:fmaa074. doi:10.1093/tropej/fmaa074.
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Choudhry N, Scott F, Edgar M, Sanger GJ, Kelly P.Reversal of pathogen-induced barrier defects in intestinal epithelial cells by contra‑pathogenicity agents.Digestive Diseases and Sciences. 2021;66:88–104. doi:10.1007/s10620-020-06121-9.
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Shrivastava A, Adorno W, Sharma Y, Ehsan L, Ali SA, Moore SR, Amadi B, Kelly P, Syed S, Brown DE.Self‑Attentive Adversarial Stain Normalisation.Pattern Recognition. 2021;12661:120–140. doi:10.1007/978-3-030-68763-2_10.
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2020
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​Kayamba V, Kelly P.Estimated 24‑hour urinary sodium excretion as a risk factor for oxidative stress in Zambian adults: A cross‑sectional study.PLOS ONE. 2020;15:e0242144. doi:10.1371/journal.pone.0242144.
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Maurice J, Lett AM, Skinner C, Lim A, Richardson M, Thomas AP, Summers PA, Vyas K, Tadbier AW, Vilar R, Kuimova MK, Miodragovic S, Vergis N, Kelly P, Cordeiro MF, Hoare J, Darzi A, Goldin R, Thursz M, Thompson AJ.Transcutaneous fluorescence spectroscopy as a tool for non‑invasive monitoring of gut function – first clinical experiences.Scientific Reports. 2020;10:16169. doi:10.1038/s41598-020-73149-2.
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Lee GO, Schillinger R, Shivakumar N, Whyte S, Huq S, Ochieng Konyole S, Chileshe J, Paredes‑Olortegui M, Owino V, Yazbeck R, Kosek MN, Kelly P, Morrison D. Optimisation, validation and field applicability of a 13C‑sucrose breath test to assess intestinal function in environmental enteropathy among children in resource poor settings: study protocol for a prospective study in Bangladesh, India, Kenya, Jamaica, Peru and Zambia. BMJ Open. 2020;10:e035841. doi:10.1136/bmjopen-2019-035841.
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Sinkala E, Vinikoor M, Siyunda AM, Zyambo K, Besa E, Nsokolo B, Wandeler G, Foster GR, Kelly P.Hepatosplenic schistosomiasis in Zambian adults is characterized by increased liver stiffness: a nested case‑control study.Heliyon. 2020;6:e04534.
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Kayamba V, Butt J, Waterboer T, Besa E, Choudhry N, Hamasuku A, Julius P, Heimburger DC, Atadhzhanov M, Kelly P.Molecular profiling of gastric cancer in a population with high HIV prevalence reveals a shift to MLH1‑loss but not the EBV subtype.Cancer Medicine. 2020;9:3445–3454. doi:10.1002/cam4.3001.
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Kayamba V, Zyambo K, Mulenga C, Mwakamui S, Tembo MJ, Shibemba A, Heimburger DC, Atadhanoz M, Kelly P.Biomass smoke is associated with gastric cancer, and probably mediated by oxidative stress and DNA damage: a case‑control study. Journal of Global Oncology. 2020;6:532–541. doi:10.1200/GO.20.00002.
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Sinkala E, Vinikoor M, Zyambo K, Besa E, Nsokolo B, Kelly P.Propranolol reduces portal vein diameter in schistosomal liver disease with portal hypertension: a prospective cohort study. American Journal of Tropical Medicine and Hygiene. 2020;102:832–837. doi:10.4269/ajtmh 19-0452.
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Besa E, Chandwe K, Banda R, Munalula L, Kalomo L, Amadi B, Kelly P. Glucagon-like peptide 2 concentrations vary in Zambian children during diarrhoea, in malnutrition, and seasonally. Journal of Pediatric Gastroenterology and Nutrition. 2020;70:513–520. doi:10.1097/MPG.0000000000002633.
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Liu T‑C, VanBuskirk K, Ali A, Kelly P, Holtz LR, Yilmaz OH, Sadiq K, Iqbal N, Amadi B, Syed S, Ahmed T, Moore S, Ndao IM, Isaacs MH, Pfeifer JD, Atlas H, Tarr PI, Denno DM, Moskaluk CA. A novel histological index for evaluation of environmental enteric dysfunction identifies geographic‑specific features of enteropathy among children with suboptimal growth. PLOS Neglected Tropical Diseases. 2020;14:e0007975. doi:10.1371/journal.pntd.0007975.
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Nehanda S, Mulundu G, Kelly P. Prevalence of Clostridium difficile and its toxins in hospital patients with diarrhoeal diseases in Lusaka, Zambia.Transactions of the Royal Society of Tropical Medicine and Hygiene. 2020;114:86–90. doi:10.1093/trstmh/trz07.
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Kowsari K, Sali R, Khan MN, Adorno W, Ali SA, Moore SR, Amadi BC, Kelly P, Syed S, Brown DE.Diagnosis of celiac disease and environmental enteropathy on biopsy images using color balancing on Convolutional Neural Networks.In: Proceedings of the Future Technologies Conference (FTC 2019). 2020;1069:750–765. doi:10.1007/978-3-030-32520-6_55.
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Vinikoor M, Sinkala E, Kanunga A, Muchimba M, Zanolini A, Saag M, Pry J, Nsokolo B, Chisenga T, Kelly P.Eligibility for hepatitis B antiviral therapy among adults in the general population in Zambia.PLOS ONE. 2020;15:e0227041. doi:10.1371/journal.pone.0227041.
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Maurice J, Lett AM, Skinner C, Lim A, Richardson M, Thomas AP, Summers PA, Vyas K, Tadbier AW, Vilar R, Kuimova MK, Miodragovic S, Vergis N, Kelly P, Cordeiro MF, Hoare J, Darzi A, Goldin R, Thursz M, Thompson AJ.Transcutaneous fluorescence spectroscopy as a tool for non‑invasive monitoring of gut function – first clinical experiences.Scientific Reports. 2020;10:16169. doi:10.1038/s41598-020-73149-2.
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Lee GO, Schillinger R, Shivakumar N, Whyte S, Huq S, Ochieng Konyole S, Chileshe J, Paredes‑Olortegui M, Owino V, Yazbeck R, Kosek MN, Kelly P, Morrison D. Optimisation, validation and field applicability of a 13C‑sucrose breath test to assess intestinal function in environmental enteropathy among children in resource poor settings: study protocol for a prospective study in Bangladesh, India, Kenya, Jamaica, Peru and Zambia. BMJ Open. 2020;10:e035841. doi:10.1136/bmjopen-2019-035841.
Read the full article on Google Scholar
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Sinkala E, Vinikoor M, Siyunda AM, Zyambo K, Besa E, Nsokolo B, Wandeler G, Foster GR, Kelly P.Hepatosplenic schistosomiasis in Zambian adults is characterized by increased liver stiffness: a nested case‑control study.Heliyon. 2020;6:e04534.
Read the full article on Google Scholar
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Kayamba V, Butt J, Waterboer T, Besa E, Choudhry N, Hamasuku A, Julius P, Heimburger DC, Atadhzhanov M, Kelly P.Molecular profiling of gastric cancer in a population with high HIV prevalence reveals a shift to MLH1‑loss but not the EBV subtype. Cancer Medicine. 2020;9:3445–3454. doi:10.1002/cam4.3001.
Read the full article on Google Scholar
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Kayamba V, Zyambo K, Mulenga C, Mwakamui S, Tembo MJ, Shibemba A, Heimburger DC, Atadhanoz M, Kelly P.Biomass smoke is associated with gastric cancer, and probably mediated by oxidative stress and DNA damage: a case‑control study. Journal of Global Oncology. 2020;6:532–541. doi:10.1200/GO.20.00002.
Read the full article on Google Scholar
-
Sinkala E, Vinikoor M, Zyambo K, Besa E, Nsokolo B, Kelly P.Propranolol reduces portal vein diameter in schistosomal liver disease with portal hypertension: a prospective cohort study. American Journal of Tropical Medicine and Hygiene. 2020;102:832–837. doi:10.4269/ajtmh 19-0452.
Read the full article on Google Scholar
-
Besa E, Chandwe K, Banda R, Munalula L, Kalomo L, Amadi B, Kelly P. Glucagon‑like peptide 2 concentrations vary in Zambian children during diarrhoea, in malnutrition and seasonally. Journal of Pediatric Gastroenterology and Nutrition. 2020;70:513–520. doi:10.1097/MPG.0000000000002633.
Read the full article on Google Scholar
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Liu T‑C, VanBuskirk K, Ali A, Kelly P, Holtz LR, Yilmaz OH, Sadiq K, Iqbal N, Amadi B, Syed S, Ahmed T, Moore S, Ndao IM, Isaacs MH, Pfeifer JD, Atlas H, Tarr PI, Denno DM, Moskaluk CA. A novel histological index for evaluation of environmental enteric dysfunction identifies geographic‑specific features of enteropathy among children with suboptimal growth. PLOS Neglected Tropical Diseases. 2020;14:e0007975. doi:10.1371/journal.pntd.0007975.
Read the full article on Google Scholar
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Nehanda S, Mulundu G, Kelly P. Prevalence of Clostridium difficile and its toxins in hospital patients with diarrhoeal diseases in Lusaka, Zambia.Transactions of the Royal Society of Tropical Medicine and Hygiene. 2020;114:86–90. doi:10.1093/trstmh/trz07.
Read the full article on Google Scholar
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Kowsari K, Sali R, Khan MN, Adorno W, Ali SA, Moore SR, Amadi BC, Kelly P, Syed S, Brown DE. Diagnosis of celiac disease and environmental enteropathy on biopsy images using colour balancing on Convolutional Neural Networks. In: Proceedings of the Future Technologies Conference (FTC 2019). 2020;1069:750–765. doi:10.1007/978-3-030-32520-6_55.
Read the full article on Google Scholar
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Vinikoor M, Sinkala E, Kanunga A, Muchimba M, Zanolini A, Saag M, Pry J, Nsokolo B, Chisenga T, Kelly P.Eligibility for hepatitis B antiviral therapy among adults in the general population in Zambia.PLOS ONE. 2020;15:e0227041. doi:10.1371/journal.pone.0227041.
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2019
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Kvalsund M, Kayamba V, Kelly P, Birbeck GL, Mwansa‑Thurman C, Nyeggen Sommer I, Lamers Y, Gardiner J, Herrmann DN.Is folate deficiency a common cause of distal symmetric polyneuropathy in Zambian clinics? Journal of the Neurological Sciences. 2019;409:116583. doi:10.1016/j.jns.2019.116583.
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Kelly P, Bell L, Amadi B, Bwakura‑Dangarembizi M, VanBuskirk K, Chandwe K, Chipunza M, Ngosa D, Chulu N, Hill S, Murch S, Playford R, Prendergast AJ. TAME trial: a multi‑arm phase 2 randomised trial of four novel interventions for malnutrition enteropathy in Zambia and Zimbabwe; a study protocol. BMJ Open. 2019;9:e027548. doi:10.1136/bmjopen-2018-027548.
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Chama M, Amadi B, Chandwe K, Besa E, Zyambo K, Shaikh N, Ndao M, Tarr P, Storer C, Head R, Kelly P.Transcriptomic analysis of enteropathy in Zambian children with severe acute malnutrition.EBioMedicine. 2019;in press.
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Syed S, Al‑Boni M, Khan MN, Sadiq K, Iqbal NT, Moskaluk CA, Kelly P, Amadi B, Ali SA, Moore SR, Brown DE.Assessment of machine learning detection of Environmental Enteropathy and celiac disease in children.JAMA Network Open. 2019;2:e195822. doi:10.1001/jamanetworkopen. 2019.5822.
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PrayGod G, Rehman AM, Wells JCK, Chisenga M, Siame J, Jeremiah K, Kasonka L, Woodd S, Changalucha J, Kelly P, Koethe JR, Heimburger DC, Friis H, Filteau S.Effects on body composition and handgrip strength of a nutritional intervention for malnourished HIV‑infected adults referred for antiretroviral therapy: a randomised controlled trial.Journal of Nutritional Science. 2019;8:e19. doi:10.1017/jns.2019.15.
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Kayamba V, Shibemba A, Zyambo K, Heimburger DC, Morgan D, Kelly P.HIV related hypochlorhydria does not appear to respond to anti‑retroviral therapy in Zambian adults: a case control study.Pan African Medical Journal. 2019;31:128. doi:10.11604/pamj.2018.31.128.11850.
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Kayamba V, Kelly P. Delayed referral for diagnostic endoscopy is a contributing factor to late gastric cancer diagnosis in Zambia.Health Press Zambia Bulletin. 2019;3:14–19.
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Bwakura‑Dangarembizi M, Amadi B, Bourke CD, Robertson RC, Mwapenya B, Chandwe K, Kapoma C, Chifunda K, Majo F, Ngosa D, Chakara P, Chulu N, Masimba F, Mapurisa I, Besa E, Mutasa K, Mwakamui S, Runodamoto T, Humphrey JH, Ntozini R, Wells J, Manges AR, Swann J, Walker AS, Nathoo KJ, Kelly P, Prendergast AJ.Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE‑SAM): rationale and methods of a longitudinal observational study.BMJ Open. 2019;9:e023077. doi:10.1136/bmjopen-2018-023077.
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2018
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Kayamba V, Shibemba A, Zyambo K, Heimburger DC, Morgan D, Kelly P. HIV related hypochlorhydria does not appear to respond to anti‑retroviral therapy in Zambian adults: a case-control study. Pan African Medical Journal. 2018;31:128. doi:10.11604/pamj.2018.31.128.11850.
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Kayamba V, Zyambo K, Kelly P. Presence of blood in gastric juice: A sensitive marker for gastric cancer screening in a poor resource setting. PLOS ONE. 2018;13:e0205185. doi:10.1371/journal.pone.0205185.
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Vinikoor MJ, Sinkala E, Kanunga A, Muchimba M, Nsokolo B, Chilengi R, Wandeler G, Mulenga J, Chisenga T, Bhattacharya D, Saag MS, Foster GR, Fried MW, Kelly P.Chronic hepatitis B virus monoinfection at a University hospital in Zambia.World Journal of Hepatology. 2018;10:622–628. doi:10.4254/wjh.v10.i9.622.
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Mwanza‑Lisulo M, Chomba MS, Chama M, Besa EC, Funjika E, Zyambo K, Banda R, Imikendu M, Sianongo S, Hancock REW, Lee A, Chilengi R, Stagg AJ, Namangala B, Kelly P. Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines. Vaccine. 2018;36:4134–4141. doi:10.1016/j.vaccine.2018.04.083.
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Kayamba V, Nicholls K, Morgan C, Kelly P.A seven‑year retrospective review of colonoscopy records from a single centre in Zambia. Malawi Medical Journal. 2018;30:17–21.
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Chongwe G, Michelo C, Sinkala E, Kayamba V, Nzaisenga J‑B, Drobniewski F, Kelly P. Mycobacterium avium lysate induces matrix metalloproteinase‑1 in intestinal tissue and peripheral blood: observations from selected hospital-based Zambian adults. International Journal of Infectious Diseases. 2018;71:73–81. doi:10.1016/j.ijid.2018.03.020.
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Sinkala E, Zyambo K, Besa E, Kaonga P, Nsokolo B, Kayamba V, Vinikoor M, Zulu R, Bwalya M, Foster GR, Kelly P. Rifaximin reduces markers of inflammation and bacterial 16S rRNA in Zambian adults with hepatosplenic schistosomiasis: a randomised controlled trial. American Journal of Tropical Medicine and Hygiene. 2018;98:1152–1158. doi:10.4269/ajtmh. 17-0637.
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Farràs M, Chandwe K, Mayneris‑Perxachs J, Amadi B, Louis‑Auguste J, Besa E, Zyambo K, Guerrant R, Kelly P, Swann JR. Characterizing the metabolic phenotype of intestinal villus blunting in Zambian children with severe acute malnutrition and persistent diarrhoea. PLOS ONE. 2018;13:e0192092. doi:10.1371/journal.pone.0192092.
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Syed S, Dinallo V, Iqbal N, Di Iorio L, Di Fusco D, Guleria S, Amadi BC, Sadiq K, Moskaluk C, Ali A, Kelly P, Monteleone G. High SMAD7 and p‑SMAD2,3 expression is associated with environmental enteropathy in children. PLOS Neglected Tropical Diseases. 2018;12:e0006224. doi:10.1371/journal.pntd.0006224.
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Mutengo MM, Mduluza T, Kelly P, Mwansa JCL, Kwenda G, Musonda P, Chipeta J. Low IL‑6, IL‑10, TNF‑α and high IL‑13 cytokine levels are associated with severe hepatic fibrosis in Schistosoma mansoni chronically exposed individuals. Journal of Parasitology Research. 2018;9754060. doi:10.1155/2018/9754060.
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2017
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Andrews B, Semmler MW, Muchemwa L, Kelly P, Lakhi S, Heimburger DC, Mabula C, Bwalya M, Bernard GR. Effect of an early resuscitation protocol on in‑hospital mortality among adults with sepsis and hypotension: a randomised clinical trial.JAMA. 2017;318:1233–1240. doi:10.1001/jama.2017.10913.
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Nsokolo B, Kanunga A, Sinkala E, Zyambo Z, Kumwenda D, Chamab D, Muyinda G, Vinikoor M, Ijaz S, Tedder R, Elmdaah AKA, Jones M, Chiluba C, Mudenda V, Goldin RD, Foster G, Kelly P. Stage of disease in hepatitis B virus infection in Zambian adults is associated with large cell change but not well defined using classic biomarkers. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2017;111:425–432. doi:10.1093/trstmh/trx077.
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Kayamba V, Shibemba A, Zyambo K, Heimburger D, Morgan D, Kelly P.High prevalence of gastric intestinal metaplasia detected by confocal laser endomicroscopy in Zambian adults.PLOS ONE. 2017;12:e0184272. doi:10.1371/journal.pone.0184272.
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Amadi B, Besa E, Zyambo K, Kaonga P, Louis‑Auguste J, Chandwe K, Tarr PI, Denno DM, Nataro JP, Faubion W, Sailer A, Yeruva S, Brantner T, Murray JA, Prendergast AJ, Turner JR, Kelly P. Impaired barrier function and autoantibody generation in malnutrition enteropathy in Zambia. EBioMedicine. 2017;22:191–199. doi:10.1016/j.ebiom.2017.07.017.
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Filteau S, PrayGod G, Woodd SL, Friis H, Heimburger DC, Koethe JR, Kelly P, Kasonka L, Rehman AM. Nutritional status is the major factor affecting the grip strength of African HIV patients before and during antiretroviral treatment. Tropical Medicine & International Health. 2017;22:1302–1313. doi:10.1111/tmi.12929.
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Rehman AM, Woodd SL, Heimburger DC, Koethe JR, Friis H, PrayGod G, Kasonka L, Kelly P, Filteau S.Changes in serum phosphate and potassium and their effects on mortality in malnourished African HIV‑infected adults starting antiretroviral therapy and given vitamins and minerals in lipid‑based nutritional supplements: secondary analysis from the NUSTART trial. British Journal of Nutrition. 2017;117:814–821. doi:10.1017/S0007114517000721.
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Kaonga P, Kaimoyo E, Besa E, Zyambo K, Sinkala E, Kelly P.Direct biomarkers of microbial translocation correlate with immune activation in adult Zambians with environmental enteropathy and hepatosplenic schistosomiasis. American Journal of Tropical Medicine and Hygiene. 2017; in press.
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Chongwe G, Michelo C, Kelly P. Diagnostic yield of nontuberculous mycobacteria in patients booked for endoscopy at the University Teaching Hospital, Lusaka. BMC Research Notes. 2017;10:27. doi:10.1186/s13104-017-2376-1.
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2016
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Simuyandi M, Kapulu MC, Kelly P. Antimicrobial peptide gene expression during oral vaccination: analysis of a randomised controlled trial. Clinical & Experimental Immunology. 2016;186:205–213. doi:10.1111/cei. 12848.
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Woodd SL, Kelly P, Koethe JR, PrayGod G, Rehman AM, Chisenga M, Siame J, Heimburger DC, Friis H, Filteau S.Risk factors for mortality among malnourished HIV‑infected adults eligible for antiretroviral therapy. BMC Infectious Diseases. 2016;16:562.
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Munkombwe D, Mungo TL, Michelo C, Kelly P, Chirwa S, Filteau S. Lipid‑based nutrient supplements containing vitamins and minerals attenuate renal electrolyte loss in HIV/AIDS patients starting antiretroviral therapy: a randomised controlled trial in Zambia. Clinical Nutrition ESPEN. 2016;13:e8–e14. doi:10.1016/j.clnesp.2016.03.002.
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Kelly P, Besa E, Zyambo K, Louis‑Auguste J, Lees J, Banda T, Soko R, Banda R, Amadi B, Watson A. Endomicroscopic and transcriptomic analysis of impaired barrier function and malabsorption in environmental enteropathy. PLOS Neglected Tropical Diseases. 2016;10:e0004600. doi:10.1371/journal.pntd.0004600.
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Faubion WA, Camilleri MC, Murray JA, Kelly P, Kosek M, Enders F, Larson J, Boe G, Dyer R, Singh R. A lactulose, rhamnose assay of intestinal permeability in the assessment of environmental enteric dysfunction. BMJ Global Health. 2016;1:e000066. doi:10.1136/bmjgh-2016-000066.
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Chisenga CC, Kelly P. T cell subset profile in healthy Zambian adults at the University Teaching Hospital. Pan African Medical Journal. 2016;23:103. doi:10.11604/pamj.2016.23.103.8547.
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Praygod G, Blevins M, Woodd S, Rehman A, Jeremiah K, Friis H, Kelly P, Changalucha J, Heimburger D, Filteau S, Koethe J. A longitudinal study of systemic inflammation and recovery of lean body mass among malnourished HIV‑infected adults starting antiretroviral therapy in Tanzania and Zambia. European Journal of Clinical Nutrition. 2016;70:499–504. doi:10.1038/ejcn. 2015.221.
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Amadi B, Imasiku M, Sakala M, Banda R, Kelly P. Integration of HIV care into community management of acute childhood malnutrition permits good outcomes: retrospective analysis of three years of a programme in Lusaka.PLOS ONE. 2016;11:e0149218. doi:10.1371/journal.pone.0149218.
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Asombang AW, Kayamba V, Lisulo MM, Trinkaus K, Mudenda V, Sinkala E, Mwanamakondo S, Banda T, Soko R, Kelly P. Oesophagal squamous cell cancer in a highly endemic region. World Journal of Gastroenterology. 2016;22:2811–2817. doi:10.3748/wjg.v22.i9.2811.
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Sinkala E, Kapulu M, Besa E, Zyambo K, Chisoso NJ, Foster GR, Kelly P. Hepatosplenic schistosomiasis is characterised by high blood markers of translocation, inflammation and fibrosis. Liver International. 2016;36:145–150. doi:10.1111/liv. 12891.
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Kayamba V, Monze M, Asombang AW, Zyambo K, Kelly P. Serological response to Epstein–Barr virus early antigen is associated with gastric cancer and Human immunodeficiency virus infection in Zambian adults: a case‑control study. Pan African Medical Journal. 2016;23:45. doi:10.11604/pamj.2016.23.45.8503.
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Rosa G, Kelly P, Clasen T.Consistency of use and effectiveness of household water treatment practices among urban and rural populations claiming to treat their drinking water at home: a case study in Zambia.American Journal of Tropical Medicine and Hygiene. 2016;94:445–455. doi:10.4269/ajtmh. 15-0563.
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Owino VO, Ahmed T, Freemark M, Kelly P, Loy A, Manary MJ, Loechl CU. Environmental Enteric Dysfunction and Growth Failure/Stunting in Global Child Health. Pediatrics. 2016;138(6):e20160641. doi:10.1542/peds. 2016-0641.
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Trehan I, Kelly P, Shaikh N, Manary MJ. New insights into Environmental Enteric Dysfunction. Archives of Disease in Childhood. 2016;101:741–744. doi:10.1136/archdischild-2015-309534.
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2015
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James P, Friis H, Woodd S, Rehman AM, PrayGod G, Kelly P, Koethe JR, Filteau S. Minimal impact of an iron‑fortified lipid‑based nutrient supplement on haemoglobin and iron status: a randomised controlled trial in malnourished HIV‑positive African adults starting antiretroviral therapy. British Journal of Nutrition. 2015;114:387–397. doi:10.1017/S0007114515001920.
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Chisenga CC, Filteau S, Siame J, Chisenga M, Prendergast AJ, Kelly P. T‑cell subsets predict mortality in malnourished Zambian adults initiating antiretroviral therapy. PLOS ONE. 2015;10:e0129928. doi:10.1371/journal.pone.0129928.
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Bestawros M, Chidumayo T, Blevins M, Canipe A, Bala J, Kelly P, Filteau S, Shepherd BE, Heimburger DC, Koethe JR. Increased systemic inflammation is associated with cardiac and vascular dysfunction over the first 12 weeks of antiretroviral therapy among undernourished, HIV‑infected adults in Southern Africa. Journal of AIDS Clinical Research. 2015;6:3. doi:10.4172/2155-6113.1000431.
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Kayamba V, Bateman AC, Asombang A, Shibemba A, Zyambo K, Banda T, Soko R, Kelly P. HIV infection and domestic smoke exposure, but not human papillomavirus, are risk factors for oesophageal squamous cell carcinoma in Zambia: a case‑control study. Cancer Medicine. 2015;4:588–595. doi:10.1002/cam4.434.
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Filteau S, PrayGod G, Kasonka L, Woodd S, Rehman AM, Chisenga M, Siame J, Koethe JR, Changalucha J, Michael D, Kidola J, Manno D, Larke N, Yilma D, Heimburger DC, Friis H, Kelly P. Effects on mortality of a nutritional intervention for malnourished HIV‑infected adults referred for antiretroviral therapy: a randomised controlled trial. BMC Medicine. 2015;13:17. doi:10.1186/s12916-014-0253-8.
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Rehman AM, Woodd S, PrayGod G, Chisenga M, Siame J, Koethe JR, Heimburger DC, Kelly P, Friis H, Filteau S. Effects on anthropometry and appetite of vitamins and minerals given in lipid nutritional supplements for malnourished HIV‑infected adults referred for antiretroviral therapy: results from the NUSTART randomised controlled trial. Journal of Acquired Immune Deficiency Syndromes. 2015;68:405–412. doi:10.1097/QAI.0000000000000483.
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Rehman AM, Chisenga M, Siame J, Sampson G, Woodd S, PrayGod G, Koethe JR, Kelly P, Filteau S. Appetite testing in HIV‑infected African adults recovering from malnutrition and given antiretroviral therapy (ART). Public Health Nutrition. 2015;18:742–751. doi:10.1017/S1368980014000718.
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Prendergast A, Kelly P. Interactions between intestinal pathogens, enteropathy and malnutrition in developing countries. Current Opinion in Infectious Diseases. 2015;29:229–236. doi:10.1097/QCO.0000000000000261.
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Mwanza‑Lisulo M, Kelly P. Potential for use of retinoic acid as an oral vaccine adjuvant. Philosophical Transactions of the Royal Society B. 2015;370:20140145. doi:10.1098/rstb. 2014.0145.
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Chisenga CC, Kelly P. A review of human Selenium requirements, disease and immune function.Medical Journal of Zambia. 2015; in press.
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2014
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Zulu J, Mwansa‑Lisulo M, Besa E, Kaonga P, Chisenga CC, Chomba M, Simuyandi M, Banda R, Kelly P. Improving validity of informed consent for biomedical research in Zambia using a laboratory exposure intervention. PLOS ONE. 2014;9:e108305. doi:10.1371/journal.pone.0108305.
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Canipe A, Chidumayo T, Blevins M, Bestawros M, Bala J, Kelly P, Filteau S, Shepherd BE, Heimburger DC, Koethe JR. A 12‑week longitudinal study of microbial translocation and systemic inflammation in undernourished HIV‑infected Zambians initiating antiretroviral therapy. BMC Infectious Diseases. 2014;14:521. doi:10.1186/1471-2334-14-521.
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Mwanza‑Lisulo M, Kapulu MC, Banda R, Sinkala E, Kayamba V, Sianongo S, Kelly P. Adjuvant potential of low dose all‑trans retinoic acid during oral typhoid vaccination in Zambian men. Clinical & Experimental Immunology. 2014;175:468–475. doi:10.1111/cei.12238.
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Asombang A, Kayamba V, Turner‑Moss E, Banda L, Colditz G, Mudenda V, Zulu R, Sinkala E, Kelly P. Gastric malignancy survival in Zambia, Southern Africa: A two‑year follow‑up study. Medical Journal of Zambia. 2014;41:13–18.
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Kayamba V, Chomba MS, Kelly P. Short-term micronutrient‑antioxidant supplementation has no impact on a serological marker of gastric atrophy in Zambian adults: retrospective analysis of a randomised controlled trial. BMC Gastroenterology. 2014;14:52. doi:10.1186/1471-230X-14-52.
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Louis‑Auguste J, Greenwald S, Simuyandi M, Soko R, Banda R, Kelly P. High dose multiple micronutrient supplementation improves villous morphology in environmental enteropathy without HIV enteropathy: results from a double‑blind randomised placebo controlled trial in Zambian adults. BMC Gastroenterology. 2014;14:15. doi:10.1186/1471-230X-14-15.
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Jacobs C, Chiluba C, Phiri C, Mwanza‑Lisulo M, Hill P, Ijaz S, Kelly P. Seroepidemiology of Hepatitis E virus infection in an urban population in Zambia: strong association with HIV and environmental enteropathy. Journal of Infectious Diseases. 2014;209:652–657. doi:10.1093/infdis/jit409.
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Kelly P, Saloojee H, Chen J, Chung RT. Non‑communicable disease in HIV infected adults in Africa: gastrointestinal, hepatic and nutritional disorders. Journal of Acquired Immune Deficiency Syndromes. 2014;67(Suppl 1):S79–S86. doi:10.1097/QAI.0000000000000260.
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2013
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Peletz R, Simuyandi M, Simunyama M, Sarenje K, Kelly P, Clasen T. Follow‑up study to assess the use and performance of household filters in Zambia. American Journal of Tropical Medicine and Hygiene. 2013;89:1190–1194. doi:10.4269/ajtmh. 13-0054.
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Payne L, Turner‑Moss E, Mutengo M, Asombang A, Kelly P. Prevalence of schistosome antibodies and hepatosplenic signs and symptoms among patients from Kaoma, Western Province, Zambia. BMC Research Notes. 2013;6:344. doi:10.1186/1756-0500-6-344.
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Kayamba V, Asombang AW, Mudenda V, Lisulo MM, Sinkala E, Mwanamakondo S, Mweemba I, Kelly P.Gastric adenocarcinoma in Zambia: a case‑control study of HIV, lifestyle risk factors, and biomarkers of pathogenesis.South African Medical Journal. 2013;103:255–259. doi:10.7196/SAMJ.6159.
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Asombang AW, Kayamba V, Mwanza‑Lisulo M, Colditz G, Mudenda V, Yarasheki K, Chott R, Rubin D, Gyawali CP, Sinkala E, Mwanamakondo S, Anderson‑Spearie C, Kelly P. Gastric cancer in Zambian adults: a prospective case‑control study assessing dietary intake and antioxidant status using isoprostane excretion. American Journal of Clinical Nutrition. 2013;97:1029–1035. doi:10.3945/ajcn. 112.051284.
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2012
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Peletz R, Simunyama M, Sarenje K, Baisley K, Filteau S, Kelly P, Clasen T.Assessing water filtration and safe storage in households with young children of HIV‑positive mothers: a randomised controlled trial in Zambia.PLOS ONE. 2012;7:e46548. doi:10.1371/journal.pone.0046548.
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Banda R, Yambayamba V, Lalusha BD, Sinkala E, Kapulu MC, Kelly P. Safety of live, attenuated oral vaccines in HIV infected Zambian adults. Oral vaccines in HIV. Vaccine. 2012;30:5656–5660. doi:10.1016/j.vaccine.2012.06.079.
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2011
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Peletz R, Simuyandi M, Sarenje K, Baisley K, Kelly P, Filteau S, Clasen T. Drinking water quality, feeding practices and diarrhea among children under 2 years of HIV‑positive mothers in peri‑urban Zambia. American Journal of Tropical Medicine and Hygiene. 2011;85:318–326. doi:10.4269/ajtmh 2011.11-0140.
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Psutka R, Peletz R, Michelo S, Kelly P, Clasen T. Assessing the microbiological performance and potential cost of boiling drinking water in urban Zambia. Environmental Science & Technology. 2011;45:6095–6101. doi:10.1021/es2004045.
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Harris J, Kelly P, Filteau S.Interactions between HIV, dietary diversity and socio‑economic position in an urban African setting. Medical Journal of Zambia. 2011;37:56–61.
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Kapulu MC, Simuyandi M, Sianongo S, Mutale M, Katubulushi M, Kelly P. Differential changes in expression of intestinal antimicrobial peptide genes during Ascaris lumbricoides infection in Zambian adults do not respond to helminth eradication. Journal of Infectious Diseases. 2011;203:1464–1473.
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- Sinkala E, Katubulushi M, Sianongo S, Obwaller A, Kelly P. In a trial of the use of miltefosine to treat HIV‑related cryptosporidiosis in Zambian adults, extreme metabolic disturbances contribute to high mortality. Annals of Tropical Medicine and Parasitology. 2011;105:129–134.
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Hardwick RJ, Machado LR, Zuccherato LW, Antolinos S, Xue Y, Shawa N, Gilman RH, Cabrera L, Berg DE, Tyler‑Smith C, Kelly P, Tarazona‑Santos E, Hollox EJ. A worldwide analysis of beta‑defensin copy number variation suggests recent selection of a high‑expressing DEFB103 gene copy in East Asia. Human Mutation. 2011;32:743–750.
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Dhaliwal W, Shawa T, Khanam M, Jagatiya P, Simuyandi M, Ndulo N, Bevins CL, Sanderson IR, Kelly P. Intestinal antimicrobial gene expression: impact of micronutrients in malnourished adults during a randomised trial. Journal of Infectious Diseases. 2010 (published online in 2011 context):202:971–978.
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2010
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Dhaliwal W, Shawa T, Khanam M, Jagatiya P, Simuyandi M, Ndulo N, Bevins CL, Sanderson IR, Kelly P. Intestinal antimicrobial gene expression: impact of micronutrients in malnourished adults during a randomised trial. Journal of Infectious Diseases. 2010;202:971–978. doi:10.1086/655901.
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Kelly P, Shawa T, Mwanamakondo S, Soko R, Smith G, Barclay GR, Sanderson IR.Gastric and intestinal barrier impairment in tropical enteropathy and HIV: limited impact of micronutrient supplementation during a randomised controlled trial. BMC Gastroenterology. 2010;10:72. doi:10.1186/1471-230X-10-72.
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Papadia C, Kelly P, Caini S, Corazza GR, Shawa T, Franze A, Forbes A, Di Sabatino A. Plasma citrulline as a quantitative biomarker of HIV‑associated villous atrophy in a tropical enteropathy population.Clinical Nutrition. 2010;xx:1–6 (early online).
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Kingori P, Muchimba M, Sikateyo B, Amadi B, Kelly P. ‘Rumours’ and clinical trials: a retrospective examination of a paediatric malnutrition study in Zambia. BMC Public Health. 2010;10:556. doi:10.1186/1471-2458-10-556.
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2009
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Amadi B, Mwiya M, Sianongo S, Payne L, Watuka A, Katubulushi M, Kelly P. High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial. BMC Infectious Diseases. 2009;9:195. doi:10.1186/1471-2334-9-195.
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Sinkala E, Gray S, Zulu I, Mudenda V, Zimba L, Vermund S, Drobniewski F, Kelly P. Clinical and ultrasonographic features of abdominal tuberculosis in HIV positive adults in Zambia. BMC Infectious Diseases. 2009;9:44. doi:10.1186/1471-2334-9-44.
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Dhaliwal W, Kelly P, Bajaj‑Elliott M. Differential effects of Staphylococcal enterotoxin B (SEB)‑mediated immune activation on constitutive and inducible small intestinal defensins. Clinical & Experimental Immunology. 2009;156:263–270. doi:10.1111/j.1365-2249.2009.03899.x.
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Shawa TS, Sianongo S, Akokwa I, Mwansa J, Nchito MF, Kelly P. Changes in serum cytokine concentration after praziquantel treatment in Zambian children with schistosomiasis. Medical Journal of Zambia. 2009;36:6–12.
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Amadi B, Fagbemi A, Kelly P, Mwiya M, Torrente F, Salvestrini C, Day RM, Golden MH, Eklund E, Freeze HH, Murch SH. Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus. American Journal of Clinical Nutrition. 2009;89:592–600. doi:10.3945/ajcn 2008.26703.
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Kelly P, Todd J, Sianongo S, Mwansa JCL, Sinsungwe H, Katubulushi M, Farthing MJG, Feldman RAF. Susceptibility to intestinal infection and diarrhoea in Zambian adults in relation to HIV status and CD4 count. BMC Gastroenterology. 2009;9:7. doi:10.1186/1471-230X-9-7.
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2008
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Zulu I, Njobvu L, Hassan G, Shawa T, Kelly P. Cytokine activation is predictive of mortality in Zambian patients with AIDS‑related diarrhoea. BMC Infectious Diseases. 2008;8:156. doi:10.1186/1471-2334-8-156.
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Kelly P, Katubulushi M, Todd J, Banda R, Yambayamba V, Fwoloshi M, Zulu I, Kafwembe E, Yavwa F, Sanderson IR, Tomkins A. Micronutrient supplementation has a limited effect on intestinal infectious disease and mortality in a Zambian population of mixed HIV status: a cluster randomized trial. American Journal of Clinical Nutrition. 2008;88:1010–1017.
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Kaile T, Zulu I, Lumayi R, Ashman N, Kelly P. Inappropriately low aldosterone concentrations in adults with AIDS‑related diarrhoea in Zambia; a study of response to fluid challenge. BMC Research Notes. 2008;1:10. doi:10.1186/1756-0500-1-10.
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Kelly P, Katema M, Amadi B, Zimba L, Aparicio S, Mudenda V, Baboo KS, Zulu I. Gastrointestinal pathology in the University Teaching Hospital, Lusaka, Zambia – review of endoscopic and pathology records. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008;102:194–199.
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2006
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Mwiya M, Amadi B, Kelly P. Intestinal infection before and after nutritional rehabilitation in children recovering from persistent diarrhoea. Medical Journal of Zambia. 2006;7:19–21.
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​Kelly P, Bajaj‑Elliott M, Katubulushi M, Zulu I, Poulsom R, Feldman RA, Bevins CL, Dhaliwal W. Reduced gene expression of intestinal α‑defensins predicts diarrhoea in a cohort of Zambian adults. Journal of Infectious Diseases. 2006;193:1464–1470. doi:10.1086/503806.
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Hughes S, Kelly P. Interaction between malnutrition and immunity to parasites. Parasite Immunology. 2006;28:577–588. doi:10.1111/j.1365-3024.2006.00900.x.
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Shawa ST, Nchito M, Mwansa JCL, Kelly P. Schistosomiasis – a public health problem. Medical Journal of Zambia. 2006;7:5–7.Read the full article on Google Scholar
2003
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Dhaliwal W, Bajaj‑Elliott M, Kelly P. Intestinal defensin gene expression in human populations. Molecular Immunology. 2003;40:469–475.
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Kelly P, Hicks S, Oloya J, Mwansa JCL, Sikakwa L, Zulu I, Phillips AD.Escherichia coli enterovirulent phenotypes in Zambians with AIDS‑related diarrhoea.Transactions of the Royal Society of Tropical Medicine and Hygiene. 2003;97:573–576.
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Guinness L, Walker D, Ndubani P, Jama J, Kelly P. Surviving the impact of HIV‑related illness in the Zambian business sector. AIDS Patient Care and STDs. 2003;17:353–363.
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2002
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Amadi BC, Mwiya M, Musuku J, Watuka A, Sianongo S, Ayoub A, Kelly P. Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial. Lancet. 2002;360:1375–1380. doi:10.1016/S0140-6736(02)11401-2.
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Kelly P, Zulu I, Amadi B, Munkanta M, Banda J, Rodrigues LC, Mabey D, Feldman R, Farthing MJG. Morbidity and nutritional impairment in relation to CD4 count in a Zambian population with high HIV prevalence. Acta Tropica. 2002;83:151–158. doi:10.1016/S0001-706X(02)00108-7.
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Zulu I, Veitch A, Sianongo S, McPhail G, Feakins R, Farthing MJG, Kelly P. Albendazole chemotherapy for AIDS‑related diarrhoea in Zambia – clinical, parasitological and mucosal responses. Alimentary Pharmacology & Therapeutics. 2002;16:595–601. doi:10.1046/j.1365-2036.2002.01193.x.
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Mwansa JCL, Mutela K, Zulu I, Amadi BC, Kelly P.Antimicrobial resistance in enterobacteria from African AIDS patients.Emerging Infectious Diseases. 2002;8:92–93. Erratum: 8:540.
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2001
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Veitch A, Kelly P, Zulu I, Segal I, Farthing MJG. Tropical enteropathy: a T cell‑mediated crypt hyperplastic enteropathy. European Journal of Gastroenterology & Hepatology. 2001;13:1175–1181.
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Kelly P, Musuku J, Kafwembe E, Libby G, Zulu I, Murphy J, Farthing MJG.Impaired bioavailability of vitamin A in adults and children with persistent diarrhoea in Zambia. Alimentary Pharmacology & Therapeutics. 2001;15:973–979.
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Fernando N, Holton J, Zulu I, Vaira D, Mwaba P, Kelly P. Helicobacter pylori infection in an urban Zambian population. Journal of Clinical Microbiology. 2001;39:1323–1327.
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Amadi BC, Kelly P, Mwiya M, Mulwazi E, Sianongo S, Changwe F, Thomson M, Hachungula J, Watuka A, Walker‑Smith JA, Chintu C. Intestinal and systemic infection, HIV and mortality in Zambian children with persistent diarrhoea and malnutrition. Journal of Pediatric Gastroenterology and Nutrition. 2001;32:550–554.
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Sianongo S, McDonald V, Kelly P. A technique for detection of microsporidia adapted for use in developing countries. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2001;95:605–607.
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Kafwembe E, Kelly P, Ngalande P. Vitamin A in HIV infection and AIDS. East African Medical Journal. 2001;78:451–453.
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Veitch AM, Kelly P, Zulu I, McDonald TT, Farthing MJG. Lack of evidence for small intestinal mucosal T cell activation as a pathogenic mechanism in African HIV‑associated enteropathy. Digestive Diseases and Sciences. 2001;46:1133–1138.
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1999
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Kelly P, Musonda R, Kafwembe E, Kaetano L, Keane E, Farthing MJG. Micronutrient supplementation for the AIDS diarrhoea-wasting syndrome in Zambia: a randomised controlled trial. AIDS. 1999;13:495–500.
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Pollok R, Zulu I, Kelly P. HIV and the gut. Int J Gastroenterol. 1999;4:13–15.
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1998
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Kelly P, Makumbi FA, Carnaby S, Simjee AE, Luo NP, Farthing MJG. Variable distribution of Cryptosporidium parvum in small and large intestine in AIDS revealed by polymerase chain reaction. Eur J Gastro Hepatol. 1998;10:855–858.
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Kelly P, Feldman RA, Ndubani P, Baboo KS, Timæus I, Farthing MJG, Wallman S. High adult mortality in Lusaka. Lancet. 1998;351:883. [Research Letter]
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Ballinger A, Kelly P, Hallyburton E, Besser R, Farthing MJG. Plasma leptin in chronic inflammatory bowel disease and HIV: implications for the pathogenesis of anorexia and weight loss. Clin Sci. 1998;94:479–483.
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Nchito M, Kelly P, Sianongo S, Luo NP, Feldman RA, Farthing MJG, Baboo KS. Cryptosporidiosis in urban Zambian children: an analysis of risk factors. Am J Trop Hyg. 1998;59:435–437.
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Ndubani P, Kelly P, Farthing MJG, Wallman S. Local understandings of adult diarrhoeal disease and its treatment in an area of high HIV seroprevalence in Zambia. Trop Med Int Health. 1998;3:783–787.
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Veitch AM, Kelly P, Segal I, Spies SK, Farthing MJG. Does sucrase deficiency in black South Africans protect against colonic disease?Lancet. 1998;351:183. [Research Letter]
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1997
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Kelly P, Nchito M, Baboo KS, Ndubani P, Okeowo NP, Luo NP, Feldman RA, Farthing MJG. Cryptosporidiosis in adults in Lusaka, Zambia, and its relationship to oocyst contamination of drinking water. J Infect Dis. 1997;176:1120–1123.
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Kelly P, Davies SE, Mandanda B, Veitch A, McPhail G, Zulu I, Drobniewski F, Fuchs D, Summerbell C, Luo NP, Pobee JOM, Farthing MJG. Enteropathy in Zambians with HIV related diarrhoea: regression modelling of potential determinants of mucosal damage. Gut. 1997;41:811–816.
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1996
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Kelly P, Summerbell C, Ngwenya B, Mandanda B, Hosp M, Luo N, Fuchs D, Wachter H, Pobee JOM, Farthing MJG.Systemic immune activation as a potential determinant of wasting in Zambians with HIV related diarrhoea. Q J Med. 1996;89:831–837
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Kelly P, Lungu F, Keane E, Baggaley R, Kazembe F, Pobee JOM, Farthing MJG. Albendazole chemotherapy for treatment of diarrhoea in patients with AIDS in Zambia: a randomised double blind controlled trial.BMJ. 1996;312:1187–1191.
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- Kelly P, Baboo KS, Woolf M, Ngwenya B, Luo N, Farthing MJG. Prevalence and aetiology of persistent diarrhoea in adults in urban Zambia. Acta Tropica. 1996;61:183–190.
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